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In the transition to a climate-neutral economy by 2050, some manufacturing industries will need to undertake particularly profound transformations. These transformations will have major implications for production technologies and costs, energy and raw materials requirements and infrastructure needed to provide access to energy, raw materials, and transport. These manufacturing activities are regionally concentrated, hence the transformations will have local implications for regional development and employment. They may change skill requirements, redistribute jobs across locations, decrease jobs in some sectors and increase them in others. Hence, understanding regional implications of the industrial transition is essential to ensure a just transition and to allow regions to benefit from the transformations.